What Is Breast Cancer - 937 Words

Breast cancer is one of the most common cancers and the second leading cause of cancer-related death among women in the United States. Up to 6% of breast cancers are advanced or metastatic at the time of diagnosis, requiring chemotherapy1, 2. Aberrant, accelerated growth is a hallmark of cancer3, including breast cancer. The rapid expansion of treatments targeted to aberrant cell growth – for example, cell cycle targeted chemotherapies for the treatment of metastatic breast cancer – allows for precise targeting of specific alterations in tumor cell proliferation pathway with the goal of reducing tumor cellular proliferation and increase tumor cell death while minimizing toxicities associated with chemotherapy. The growing application of†¦show more content†¦This review focuses on currently investigational cell proliferation imaging PET radiotracers to evaluate tumor proliferation in the setting of cell cycle targeted chemotherapy and endocrine therapy for meta static breast cancer. We review the underlying biology associated with cancer proliferation and cell cycle-targeted drugs, followed by a review of the mechanistic underpinnings of cell proliferation tracers, and finally, their application to therapy targeted to aberrant breast cancer proliferation. Cell cycle and proliferation control: Enhancing endocrine therapy with combination with cell cycle targeting agents Proliferating cells must progress through 4 phases of cell cycle to divide (G1, S, G2 and M); however, they may exit cell cycle and enter quiescence (G0) when stressed or deprived of their biological stimuli (for example in breast cancer with estrogen deprivation)7, 8. Cyclin-dependent kinases (CDKs) play a key role in controlling cell cycle progression. Among these kinases, CDK4/6 is the key regulator of G1 to S transition by controlling transcription of genes necessary for cell cycle progression. This kinase is activated upon binding to cyclin D, leading to expression of genes required for S-phase entry9. This tightly regulated cyclin D-CDK4/6 complex isShow MoreRelatedWhat is Breast Cancer? What is the Cause of it?1328 Words   |  6 PagesWhat is Breast Cancer? What is the Cause of it? Breast cancer is cancer cells that develop in the breast of a woman. The most common type of breast cancer is ductal carcinoma in situ. The cancer cells develop in the milk ducts of the breast. Doctors and researchers do not exactly know the cause of cancer. All they know is that it usually occurs when a cell’s DNA is damaged. When cells in the breast start to develop abnormally they begin to develop quicker than the normal cells. They also keep multiplyingRead MoreWhat Is Biotechnology And Its Ramification To Breast Cancer1101 Words   |  5 PagesBiotechnology and its Ramification to Breast Cancer According to the Centers of Disease Control and Prevention (CDC) in 2014; 236,968 women and 2,141 men in the United States were diagnosed with breast cancer. And 41,211 women and 465 men in the United States died from breast cancer (U.S. Cancer Statistics Working Group, 2017). That volume of death could have drastically been decreased if the clinicians, physicians, and oncologists utilized the Mammaprint. To understand the way Mammaprint makesRead MoreEssay Breast Cancer961 Words   |  4 PagesBreast cancer is everywhere. The pink ribbons, the â€Å"I heart boobies† bracelets, and the thousands of breast cancer walks all over the United States. These all contribute to breast cancer organizations. Over one hundred million dollars has been raised to support breast cancer. 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However, breast cancer seems to grab more attention due to its recurrence. According to an article in Opposing Viewpoints, breast cancer is a disease in which abnormal breast cells begin to grow uncontrollably, forming tumors. Breast cancer is highly common amongst today’s society, and has sparked much research in the medical field worldwide. Contrary to popular belief, breast cancer is not a modern illnessRead MoreBreast Cancer Prevention and Education Essay1695 Words   |  7 PagesAccording to the American Cancer Society, â€Å"Breast cancer is the common disease of women in the United States, other than skin cancer.† After lung cancer, it is the leading secondary cause of cancer death in women. It helps to have some basic facts about the normal makeup of the breasts to understand breast cancer. In the past, this disease was one of the most feared forms of cancer due to its fatality rate and because complete recovery often required breast removal. The best way to fight this diseaseRead MoreCauses And Treatments Of Breast Cancer1587 Words   |  7 PagesWHAT IS CANCER? Cancer can be said to be a generic term for a large collection of diseases that can have an effect on any part of the body, it can be sometimes called malignant tumors and neoplasms. In other words, cancer can be defined as the rapid creation of abnormal cells that grow beyond their normal boundaries, which are capable of invading adjoining parts of the body and spread through to the organs. However, this process is referred to as metastasis, which is the major cause of death fromRead MoreBreast Cancer : A Disease1737 Words   |  7 PagesWyrick 1 Leah Wyrick Ms. Basinger AP Language and Composition 12 May 2017 Breast Cancer Breast cancer is a disease in which most commonly occurs in all women no matter their size, shape, race, or ethnicity. About one in eight women will be diagnosed with breast cancer every year, a fatal disease if not discovered early. Early detection of breast cancer is key so that cancerous cells found in the breast do not spread through other parts of the body. On a positive note, however, significant advancesRead MoreLeah Wyrick. Ms. Basinger. Ap Language And Composition.1685 Words   |  7 PagesLeah Wyrick Ms. Basinger AP Language and Composition 12 May 2017 Breast Cancer Breast cancer is a disease in which most commonly occurs in all women no matter their size, shape, race, or ethnicity. About one in eight women will be diagnosed with breast cancer every year, a fatal disease if not discovered early. Early detection of breast cancer is key so that cancerous cells found in the breast do not spread through other parts of the body. On a positive note, however, significant advances have beenRead MoreOverview of Breast Cancer Essay1015 Words   |  5 PagesIf you or a loved one were diagnosed with breast cancer, how would you feel? You would probably feel very afraid and worried. Breast cancer is a common and potentially deadly form of cancer that affects both men and women. There are risk factors for getting the disease and there are different types of treatment for people who have been diagnosed with the disease. There are also steps that people can take to try to prevent getting breast cancer or at least catch it early. Luckily there are many